Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, SE-971 87 Luleå, Sweden.
Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, SE-971 87 Luleå, Sweden.
Bioresour Technol. 2021 Feb;321:124457. doi: 10.1016/j.biortech.2020.124457. Epub 2020 Dec 3.
To meet environmental sustainability goals, microbial oils have been suggested as an alternative to petroleum-based products. At present, microbial fermentation for oil production relies on pure sugar-based feedstocks. However, these feedstocks are expensive and are in limited supply. Volatile fatty acids, which are generated as intermediates during anaerobic digestion of organic waste have emerged as a renewable feedstock that has the potential to replace conventional sugar sources for microbial oil production. They comprise short-chain (C2 to C6) organic acids and are employed as building blocks in the chemical industry. The present review discusses the use of oleaginous microorganisms for the production of biofuels and added-value products starting from volatile fatty acids as feedstocks. The review describes the metabolic pathways enabling lipogenesis from volatile fatty acids, and focuses on strategies to enhance lipid accumulation in oleaginous microorganisms by tuning the ratios of volatile fatty acids generated via anaerobic fermentation.
为了实现环境可持续性目标，人们提出微生物油脂可以作为石油基产品的替代品。目前，用于生产油脂的微生物发酵依赖于纯糖基原料。然而，这些原料价格昂贵，供应有限。挥发性脂肪酸是有机废物厌氧消化过程中的中间产物，现已成为一种可再生的原料，有可能替代传统的微生物油脂生产用糖源。它们由短链（C2 到 C6）有机酸组成，可用作化学工业的构建模块。本综述讨论了利用产油微生物从挥发性脂肪酸作为原料生产生物燃料和高附加值产品。该综述描述了从挥发性脂肪酸进行脂肪生成的代谢途径，并侧重于通过调节厌氧发酵产生的挥发性脂肪酸的比例来优化产油微生物中脂质积累的策略。
