Post Graduate Program of Nutrition, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Rua Botucatu, 862-Vila Clementino, São Paulo, SP 04020-050, Brazil.
Post Graduate Program of Nutrition, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Rua Botucatu, 862-Vila Clementino, São Paulo, SP 04020-050, Brazil.
Cytokine. 2020 Jul;131:155111. doi: 10.1016/j.cyto.2020.155111. Epub 2020 May 1.
The expansion of adipose tissue increases leptin secretion associated with a reduction of adiponectin concentration, which negatively affects health of adolescents with obesity. This study aims to investigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin, adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction.
Thirty-eight adolescents (14-19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (<5%-n = 18) or greater than or equal to 5% (≥5%-n = 20). Leptin decreased in whole group after therapy, while adiponectin, and adiponectin/leptin ratio increased. Additionally, body composition was improved. Only the group who lost ≥5% of body weight could reduce the inflammatory state.
The interdisciplinary therapy contributes to improve cardiometabolic parameters that could be involved on inflammation in adolescents with obesity, this improvement occurred mainly when the weight loss is ≥5% of body weight. It could be a target for control the inflammatory process related to obesity in adolescents.
脂肪组织的扩张会增加与脂联素浓度降低相关的瘦素分泌，这会对肥胖青少年的健康产生负面影响。本研究旨在探讨非强化型跨学科治疗对心脏代谢参数的影响，包括瘦素、脂联素和脂联素/瘦素比值，因为这些参数与体重减轻的幅度有一定的依赖关系。
38 名（14-19 岁）青少年参加了为期 20 周的跨学科治疗。在基线和治疗后测量了身体成分、生化参数、瘦素和脂联素。根据总体重减轻的幅度，将青少年分为两组，小于 5%（<5%-n=18）或大于或等于 5%（≥5%-n=20）。治疗后，整个组的瘦素水平下降，而脂联素和脂联素/瘦素比值增加。此外，身体成分也得到了改善。只有体重减轻≥5%的组才能减轻炎症状态。
跨学科治疗有助于改善心脏代谢参数，这可能与肥胖青少年的炎症有关，这种改善主要发生在体重减轻≥5%的情况下。这可能是控制与肥胖相关的炎症过程的一个目标。
