Post-graduate Program of Nutrition, Universidade Federal de São Paulo, São Paulo, Brazil.
Inflammation. 2014 Feb;37(1):35-43. doi: 10.1007/s10753-013-9709-9.
The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents undergoing interdisciplinary therapy. Thirty-four obese adolescents underwent interdisciplinary therapy for 1 year. Subjects were considered hyperleptinemic if they had baseline values of leptin above 20 ng/mL for boys and 24 ng/mL for girls. Both groups showed an improvement in body composition and a reduction in carotid intima-media thickness. However, only subjects in the non-hyperleptinemic group showed an increase in adiponectin concentration after therapy. Moreover, leptin concentration was positively correlated with adiponectin and inversely correlated with PAI-1 in this group. Hyperleptinemic state may impair the attenuation of inflammation in obese adolescents undergoing interdisciplinary therapy, particularly by impeding the increase in adiponectin concentration, which is directly involved in vascular protection.
肥胖症患者体内出现的低度全身炎症可能会影响一些脂肪组织衍生的脂肪因子的作用，这些脂肪因子参与了血管功能的调节。我们试图验证高瘦素血症是否会影响接受跨学科治疗的肥胖青少年的炎症和动脉粥样硬化反应。34 名肥胖青少年接受了为期 1 年的跨学科治疗。如果男孩的瘦素基线值高于 20ng/ml，女孩的瘦素基线值高于 24ng/ml，则认为这些受试者存在高瘦素血症。两组患者的身体成分都得到了改善，颈动脉内膜-中层厚度也都有所减少。然而，只有非高瘦素血症组的受试者在治疗后，其脂联素浓度增加。此外，在该组中，瘦素浓度与脂联素呈正相关，与 PAI-1 呈负相关。高瘦素血症状态可能会损害接受跨学科治疗的肥胖青少年炎症的减弱，特别是通过阻碍脂联素浓度的增加，脂联素直接参与血管保护。
