Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Oncology School, Liga Norte Riograndense Contra o Câncer, Natal, Rio Grande do Norte, Brazil.
BMJ Open. 2020 Nov 3;10(11):e039933. doi: 10.1136/bmjopen-2020-039933.
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been growing at an accelerating rate, and has become a public health emergency. Pregnant women and their fetuses are susceptible to viral infection, and outcomes in this population need to be investigated.
PubMed, Web of Science, Embase, CINAHAL, Latin American and Caribbean Health Sciences Literature, clinicaltrials.gov, SCOPUS, Google Scholar and Cochrane Central Controlled Trials Registry will be searched for observational studies (cohort and control cases) published from December 2019 to present. This systematic review and meta-analysis will include studies of pregnant women at any gestational stage diagnosed with COVID-19. The primary outcomes will be maternal and foetal morbidity and mortality. Three independent reviewers will select the studies and extract data from the original publications. The risk of bias will be assessed using the Newcastle-Ottawa Scale for observational studies. To evaluate the strength of evidence from the included data, we will use Grading of Recommendation Assessment, Development, and Evaluation method. Data synthesis will be performed using Review Manager software V.5.2.3. To assess heterogeneity, we will compute the I statistics. Additionally, a quantitative synthesis will be performed if the included studies are sufficiently homogenous.
This study will be a review of the published data, and thus it is not necessary to obtain ethical approval. The findings of this systematic review will be published in a peer-reviewed journal.
PROSPERO 2020: CRD42020181519.
由 SARS-CoV-2 病毒引起的 COVID-19 大流行正在加速蔓延，现已构成公共卫生紧急事件。孕妇及其胎儿容易受到病毒感染，因此需要对该人群的结局进行调查。
将从 2019 年 12 月至今在 PubMed、Web of Science、Embase、CINAHAL、拉丁美洲和加勒比健康科学文献、clinicaltrials.gov、SCOPUS、Google Scholar 和 Cochrane 中心对照试验注册中心检索观察性研究（队列和对照病例）。本系统评价和荟萃分析将包括在任何妊娠阶段被诊断患有 COVID-19 的孕妇研究。主要结局指标将是母婴发病率和死亡率。三位独立评审员将从原始出版物中选择研究和提取数据。使用纽卡斯尔-渥太华量表评估观察性研究的偏倚风险。为了评估纳入数据的证据强度，我们将使用推荐评估、制定和评估方法（Grading of Recommendation Assessment, Development, and Evaluation method）进行评估。使用 Review Manager 软件 V.5.2.3 进行数据分析合成。为了评估异质性，我们将计算 I 统计量。此外，如果纳入的研究足够同质，将进行定量综合分析。
本研究是对已发表数据的综述，因此无需获得伦理批准。本系统评价的结果将发表在同行评议的期刊上。
PROSPERO 注册号：PROSPERO 2020：CRD42020181519。
