Department of Plastic and Reconstructive Surgery.
Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Sciences, King Edward Medical University, Lahore, Pakistan.
J Craniofac Surg. 2020 Jul-Aug;31(5):1228-1231. doi: 10.1097/SCS.0000000000006377.
Contour deformities of face are commonly associated with overlying skin hyperpigmentation. Such hyperpigmentation causes aesthetic problems as well as makes contour deformities more prominent. Conventional surgical and cosmetic approaches to treat hyperpigmentation have limitations and therefore it is imperative to use other innovative techniques to simultaneously heal the contour deformity and also to remove hyperpigmentation. The current study aims to evaluate the effect of autologous adipose tissue in improving contour deformities related hyperpigmentation of face. One hundred patients with contour deformities related hyper-pigmentation of overlying skin were enrolled from February 2017 to January 2018. Adipose tissue was harvested from each patient and processed under sterilized conditions. Purified fat collected in a 10cc Luer-Lok syringe was transferred to 1cc syringes and injected into affected areas of face. The patients were followed for 12 months after adipose tissue injections. Both subjective and objective assessment was performed before treatment and 12 months after adipose tissue injections. Results indicated that after adipose tissue grafting, there was a statistically significant improvement in hyperpigmentation of skin. Most of the patients were highly satisfied after use of adipose tissue injections. Image J scanning also showed significant changes in hyperpigmentation of face after adipose tissue use. In all parameters, the patient exhibited statistically significant improvement. In conclusion, autologous fat grafting is a promising and effective therapeutic approach for hyperpigmentation associated with contour deformities of face.
面部轮廓畸形通常与覆盖的皮肤色素沉着过度有关。这种色素沉着不仅会导致美容问题，还会使轮廓畸形更加明显。传统的手术和美容方法治疗色素沉着过度存在局限性，因此必须使用其他创新技术来同时治疗轮廓畸形和去除色素沉着。本研究旨在评估自体脂肪组织改善面部轮廓相关色素沉着过度的效果。2017 年 2 月至 2018 年 1 月，共招募了 100 例面部皮肤色素沉着过度相关轮廓畸形的患者。从每位患者身上采集脂肪组织，并在无菌条件下进行处理。收集到的 10cc Luer-Lok 注射器中的纯化脂肪转移到 1cc 注射器中，并注入面部受影响的区域。脂肪组织注射后，患者随访 12 个月。在治疗前和脂肪组织注射后 12 个月进行主观和客观评估。结果表明，脂肪组织移植后，皮肤色素沉着过度有显著改善。大多数患者在使用脂肪组织注射后非常满意。Image J 扫描也显示脂肪组织使用后面部色素沉着过度有显著变化。所有参数均显示患者有统计学意义的改善。总之，自体脂肪移植是治疗面部轮廓相关色素沉着过度的一种有前途且有效的治疗方法。
