Kocic Hristina, Stankovic Milica, Tirant Michael, Lotti Torello, Arsic Ivana
Clinic of Dermatology, Clinical Center Nis, University of Nis, Nis, Serbia.
Department of Pharmacy, Medical Faculty University of Nis, Nis, Serbia.
Dermatol Ther. 2020 Jul;33(4):e13511. doi: 10.1111/dth.13511. Epub 2020 Jun 18.
The use of donkey milk has a long history in external dermal application for cosmetic and medical purposes. The encapsulation of different drugs into nanoliposomes and nutrients may have many benefits for the delivery of the targeted substance. The aim of the present study is to test creams with nanoliposomes encapsulated with skimmed donkey milk, reported in our registered patent, compared with effect of the placebo cream and the untreated skin. To investigate the effect of formulated cream, we have measured the electrical capacitance, transepidermal water loss and the skin pH value. The study included 15 healthy volunteers (11 women and 4 men). The patented creams exhibited satisfactory moisturizing properties very soon after application, while hydration was reached earlier in the spots treated with night cream. Transepidermal water loss slightly decreased only after 4 weeks of treatment in each of the spots assessed. The pH value was similar after each of the treatments. Tested creams may enhance the moisture of skin very soon after application, in this way potentially enable deeper permeation of phospholipids and essential proteins, without changing the pH. It may also contribute to additional anti-aging effects.
驴奶在用于美容和医疗目的的外用皮肤护理方面有着悠久的历史。将不同药物封装到纳米脂质体和营养物质中可能对靶向物质的递送有诸多益处。本研究的目的是测试含有我们已注册专利中报道的用脱脂驴奶封装的纳米脂质体的乳膏，并与安慰剂乳膏和未处理皮肤的效果进行比较。为了研究配方乳膏的效果，我们测量了电容、经表皮水分流失和皮肤pH值。该研究纳入了15名健康志愿者（11名女性和4名男性）。专利乳膏在涂抹后很快就表现出令人满意的保湿性能，而晚霜处理的部位更早达到水合状态。在评估的每个部位，仅在治疗4周后经表皮水分流失才略有下降。每次治疗后pH值相似。测试的乳膏在涂抹后很快就能增强皮肤的水分，从而有可能使磷脂和必需蛋白质更深入地渗透，同时不改变pH值。它还可能有助于产生额外的抗衰老效果。
