新型海洋来源真菌 sp. 中的安特拉新型倍半萜类化合物
New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus sp.
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Mar Drugs. 2021 Mar 27;19(4):189. doi: 10.3390/md19040189.
Three new andrastin-type meroterpenoids penimeroterpenoids A-C (-) together with two known analogs ( and ) were isolated from the cultures of the marine-derived species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of - were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
从海洋来源的 物种（sp.）的培养物中分离得到三个新的安特拉汀型倍半萜penimeroterpenoids A-C (-)，以及两个已知类似物（和 ）。根据 1 维和 2 维（1D/2D）核磁共振（NMR）光谱和质谱分析确定了新化合物的结构。通过比较实验和计算的电子圆二色性（ECD）光谱确定了 - 的绝对构型。化合物 对 A549、HCT116 和 SW480 细胞系表现出中等的细胞毒性。
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