Department of Medicine, University of California, San Francisco, San Francisco, CA.
Department of Medicine, Massachusetts General Hospital, Boston, MA.
Liver Transpl. 2020 Aug;26(8):1030-1033. doi: 10.1002/lt.25792. Epub 2020 Jun 30.
For both children and adults with end-stage liver disease, liver transplantation represents a lifelong treatment, not a cure. The physical and psychological process of undergoing transplantation begins well before the surgery itself. Concerns regarding suffering and death from end-stage liver disease are replaced by a lifelong need for multiple medications, ongoing monitoring of graft function, and heightened vigilance for complications related not only to the transplant itself but to longterm immunosuppression. The psychological toll from the entire transplant experience on the patient and caregivers, as well as the strain that such a major treatment places on these human interactions can leave emotional scars that persist longer than the surgical healing process itself. The concept of survivorship, originally applied to patients with cancer, acknowledges the ongoing spectrum of care and support that patients and their caregivers require to optimize longterm outcomes after serious medical treatment. Transplant survivorship would expand the focus of care of a patient with end-stage liver disease beyond disease-specific issues and survival alone. This viewpoint explores the need for such a construct in the field of liver transplantation to promote a more holistic approach that encompasses the overall physical, psychological, social, and spiritual well-being of the liver transplant patient.
对于儿童和终末期肝病的成年人来说,肝移植代表着一种终身治疗,而不是治愈。接受移植的身体和心理过程早在手术本身之前就开始了。对终末期肝病的痛苦和死亡的担忧,被对长期需要多种药物、持续监测移植物功能以及对与移植本身以及长期免疫抑制相关的并发症保持高度警惕所取代。整个移植过程对患者和护理人员的心理影响,以及这种重大治疗对这些人际互动的压力,可能会留下比手术愈合过程本身更持久的情感创伤。最初应用于癌症患者的生存概念,承认患者及其护理人员在接受严重医疗治疗后需要持续的护理和支持,以优化长期结果。移植生存将扩大终末期肝病患者护理的重点范围,超出疾病特定问题和生存本身。这种观点探讨了在肝脏移植领域中建立这种结构的必要性,以促进更全面的方法,涵盖肝脏移植患者的整体身体、心理、社会和精神健康。