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韩国红参对去卵巢小鼠肝脏和子宫中双酚A影响的保护作用的比较转录组分析

Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice.

作者信息

Lee Jeonggeun, Park Joonwoo, Lee Yong Yook, Lee YoungJoo

机构信息

Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University, Kwangjin-gu, Seoul, Republic of Korea.

The Korean Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea.

出版信息

J Ginseng Res. 2020 May;44(3):519-526. doi: 10.1016/j.jgr.2020.01.008. Epub 2020 Feb 6.

DOI:10.1016/j.jgr.2020.01.008
PMID:32372874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7195581/
Abstract

BACKGROUND

Bisphenol A (BPA), known as an endocrine disruptor, is widely used in the world. BPA is reported to cause inflammation-related diseases. Korean Red Ginseng (KRG) has been used safely in human for a long time for the treatment of diverse diseases. KRG has been reported of its mitigating effect on menopausal symptoms and suppress adipose inflammation. Here, we investigate the protective effect of orally administered KRG on the impacts of BPA in the liver and uterus of menopausal mice model.

METHODS

The transcriptome analysis for the effects of BPA on mice liver was evaluated by Gene Expression Omnibus (GEO) database-based data (GSE26728). assay to evaluate the protective effect of KRG on BPA impact in ovariectomized (OVX) mice were designed and analyzed by RNA sequencing.

RESULTS

We first demonstrated that BPA induced 12 kinds of gene set in the liver of normal mice. The administration of BPA and KRG did not change body, liver, and uterine weight in OVX mice. KRG downregulated BPA-induced inflammatory response and chemotaxis-related gene expression. Several gene set enrichment analysis (GSEA)-derived inflammatory response genes increased by BPA were inhibited by KRG in OVX mice.

CONCLUSION

Our data suggest that BPA has commonly influenced inflammatory response effects on both normal and OVX mice. KRG protects against BPA impact of inflammatory response and chemotaxis in OVX mouse models. Our comparative analysis will provide new insight into the efficacy of KRG on endocrine disrupting chemicals and OVX mouse.

摘要

背景

双酚A（BPA）作为一种内分泌干扰物，在全球被广泛使用。据报道，BPA会引发炎症相关疾病。韩国红参（KRG）长期以来一直在人类中安全使用，用于治疗多种疾病。据报道，KRG对更年期症状有缓解作用，并能抑制脂肪炎症。在此，我们研究口服KRG对更年期小鼠模型肝脏和子宫中BPA影响的保护作用。

方法

通过基于基因表达综合数据库（GEO）的数据（GSE26728）评估BPA对小鼠肝脏影响的转录组分析。设计并通过RNA测序分析评估KRG对去卵巢（OVX）小鼠中BPA影响的保护作用的实验。

结果

我们首先证明BPA在正常小鼠肝脏中诱导了12种基因集。BPA和KRG的给药并未改变OVX小鼠的体重、肝脏和子宫重量。KRG下调了BPA诱导的炎症反应和趋化相关基因表达。在OVX小鼠中，KRG抑制了几种由基因集富集分析（GSEA）得出的、因BPA而增加的炎症反应基因。

结论

我们的数据表明，BPA对正常小鼠和OVX小鼠的炎症反应都有普遍影响。KRG可保护OVX小鼠模型免受BPA对炎症反应和趋化作用的影响。我们的比较分析将为KRG对内分泌干扰化学物质和OVX小鼠的功效提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/43c91de9bdb4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/7cfc528b0b71/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/00e9b24a84af/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/0641bfae0ba2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/5fcffb63604e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/43c91de9bdb4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/7cfc528b0b71/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/00e9b24a84af/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/0641bfae0ba2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/5fcffb63604e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3edd/7195581/43c91de9bdb4/gr5.jpg

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