Holmes Brandon B, Conell-Price Jessamyn, Kreple Collin J, Ashraf Davin, Betjemann John, Rosendale Nicole
Department of Neurology, University of California, San Francisco, CA, USA.
Department of Ophthalmology, University of California, San Francisco, CA, USA.
Neurohospitalist. 2020 Apr;10(2):127-132. doi: 10.1177/1941874419869713. Epub 2019 Aug 18.
Subacute sclerosing panencephalitis (SSPE) is a rare progressive neuroinfectious disease due to a late complication of the measles virus. The hallmark clinical features of this disease include behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The presence of characteristic high-amplitude periodic complexes on electroencephalography and raised antibody titers against measles in the cerebrospinal fluid help solidify the diagnosis. We present a case of a 40-year-old patient with SSPE who initially developed ophthalmologic manifestations 30 years after the primary measles infection. This case highlights both typical and atypical features of SSPE and provides a diagnostic framework for evaluating cases that fall outside of the standard scope of this disease.
亚急性硬化性全脑炎（SSPE）是一种由麻疹病毒晚期并发症引起的罕见的进行性神经感染性疾病。该疾病的标志性临床特征包括行为改变、肌阵挛、痴呆、视觉障碍以及锥体束和锥体外系体征。脑电图上特征性的高振幅周期性复合波的出现以及脑脊液中抗麻疹抗体滴度升高有助于确诊。我们报告一例40岁的SSPE患者，其在原发性麻疹感染30年后最初出现眼科表现。该病例突出了SSPE的典型和非典型特征，并为评估超出该疾病标准范围的病例提供了诊断框架。
