Babu Rajesh B, Biswas Jyotirmay
Department of Uveitis, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India.
J Neuroophthalmol. 2007 Dec;27(4):288-91. doi: 10.1097/WNO.0b013e31815b98e6.
Two patients presented with retinitis as the initial clinical manifestation of subacute sclerosing panencephalitis (SSPE), a delayed neurologic complication of measles. In one patient, the ocular involvement preceded the neurologic symptoms by 4 weeks and in the other patient by 4 years. The diagnosis of SSPE was suspected when neuropsychiatric manifestations appeared and was confirmed by the typical panencephalitic electroencephalography changes, neuroimaging features of panencephalitis, and high titers of measles antibodies in serum and cerebrospinal fluid. Although SSPE is an untreatable illness, recognition of this unusual presentation is valuable to allow earlier diagnosis and institution of palliative measures.
两名患者以视网膜炎作为亚急性硬化性全脑炎（SSPE）的初始临床表现，SSPE是麻疹的一种迟发性神经并发症。在一名患者中，眼部受累比神经症状早4周出现，在另一名患者中则早4年出现。当出现神经精神症状时怀疑为SSPE，并通过典型的全脑炎脑电图改变、全脑炎的神经影像学特征以及血清和脑脊液中高滴度的麻疹抗体得以确诊。尽管SSPE是一种无法治疗的疾病，但认识到这种不寻常的表现对于早期诊断和采取姑息措施具有重要价值。
