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他汀类药物诱导的免疫介导性坏死性肌病1例罕见病例

A Rare Case of Statin-induced Immune-mediated Necrotizing Myopathy.

作者信息

Madgula Anantha Sriharsha, Gadela Naga Vaishnavi, Singh Meghana, Chen Kai

机构信息

Internal Medicine, University of Connecticut School of Medicine, Farmington, USA.

Internal Medicine, University of Connecticut, Farmington, USA.

出版信息

Cureus. 2020 Apr 1;12(4):e7500. doi: 10.7759/cureus.7500.

DOI:10.7759/cureus.7500
PMID:32373404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7195195/
Abstract

Statin-associated myopathy comprises of a spectrum of conditions ranging from benign myalgias to statin-induced immune-mediated necrotizing myopathy. Statin-induced immune-mediated necrotizing myopathy is an autoimmune condition wherein there is a destruction of normal skeletal muscular architecture that can be severely debilitating if not recognized promptly. Given its rarity, management is a challenge. We present one such case that was managed with aggressive immunosuppression.

摘要

他汀类药物相关肌病包括一系列病症,从良性肌痛到他汀类药物诱导的免疫介导坏死性肌病。他汀类药物诱导的免疫介导坏死性肌病是一种自身免疫性疾病,其中正常骨骼肌结构遭到破坏,如果不及时识别,可能会导致严重功能障碍。鉴于其罕见性,治疗是一项挑战。我们介绍了一例通过积极免疫抑制治疗的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0722/7195195/f8d3ffa6c2d6/cureus-0012-00000007500-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0722/7195195/f8d3ffa6c2d6/cureus-0012-00000007500-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0722/7195195/f8d3ffa6c2d6/cureus-0012-00000007500-i01.jpg

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Arthritis Res Ther. 2020 Jan 8;22(1):5. doi: 10.1186/s13075-019-2093-6.
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Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.依洛尤单抗与急性冠脉综合征后的心血管结局。
N Engl J Med. 2018 Nov 29;379(22):2097-2107. doi: 10.1056/NEJMoa1801174. Epub 2018 Nov 7.
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Br J Hosp Med (Lond). 2017 Jun 2;78(6):352-353. doi: 10.12968/hmed.2017.78.6.352.
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