Wang Lu, Zhang Xianyan, Zhang Kaijin, Zhang Xiaomin, Zhu Tianjiao, Che Qian, Zhang Guojian, Li Dehai
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Front Chem. 2020 Apr 21;8:270. doi: 10.3389/fchem.2020.00270. eCollection 2020.
Overexpression of the PbrlaeA gene of the fungus HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (), whose configuration has not been reported before, and one new compound iso-fumigatin chlorohydrin (). All structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data, C NMR calculations, and ECD calculations. Compounds and exhibited cytotoxic activity against HL-60 with IC of 18.63 and 24.83 μM.
真菌HDN-12-143的PbrlaeA基因过表达导致分离出四种化合物，包括氯代烟曲霉毒素（其构型此前未见报道）和一种新化合物异氯代烟曲霉毒素。所有结构包括绝对构型均通过综合光谱数据、碳核磁共振计算和电子圆二色计算得以阐明。化合物 和 对HL-60细胞表现出细胞毒性活性，IC50分别为18.63和24.83 μM。
