Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Department of Life Sciences and Chemistry, Jacobs University Bremen gGmbH, Campus Ring 1, 28759 Bremen, Germany.
Org Biomol Chem. 2020 May 20;18(19):3761-3766. doi: 10.1039/d0ob00720j.
An unprecedented transition-metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed. This reaction was conducted under mild conditions and tolerated a wide range of coupling partners including disulfides and amines, affording the corresponding sulfinamide products in good chemical yields. Furthermore, this reaction could be used in gram-scale synthesis. This reaction enriches the research content of Selectfluor and provides a valuable vista for the convenient synthesis of sulfinamides.
开发了一种在有氧条件下以 Selectfluor 为温和氧化剂的二硫化物和胺的前所未有的过渡金属免费氧化反应。该反应在温和条件下进行，并能容忍包括二硫化物和胺在内的广泛的偶联伙伴，以良好的化学收率提供相应的亚磺酰胺产物。此外，该反应可用于克级规模合成。该反应丰富了 Selectfluor 的研究内容，为亚磺酰胺的方便合成提供了有价值的前景。
