用于可视化脂滴中一氧化氮的深度成像：发现一氧化氮与癌症化疗药物耐药性之间的关系。
Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs.
机构信息
Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, College of Chemistry and Material Science, South-central University for Nationalities, Wuhan 430074, China.
出版信息
Chem Commun (Camb). 2020 Jun 11;56(46):6233-6236. doi: 10.1039/d0cc01856b. Epub 2020 May 6.
PMID:32373871
Abstract
A near-infrared two-photon fluorescent probe (TAN) was synthesized for selective detection and deep-depth imaging of NO in lipid droplets. All results demonstrated that NO production in lipid droplets is closely correlated with the resistance to anti-tumor drugs, and NO inhibitors can effectively improve the efficacy of chemotherapeutic agents.
摘要
一种近红外双光子荧光探针（TAN）被合成出来，用于选择性检测和深层成像脂滴中的 NO。所有结果表明，脂滴中的 NO 产生与抗肿瘤药物的耐药性密切相关，NO 抑制剂可以有效提高化疗药物的疗效。
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