Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
Department of Neurosciences, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Disabil Rehabil. 2022 Jan;44(1):44-51. doi: 10.1080/09638288.2020.1755728. Epub 2020 May 6.
This study aimed to investigate the ability of the Quick Dementia Rating System (QDRS) to discriminate patients with PD who have mild cognitive impairment from those without cognitive impairment and those with dementia.
A total of 105 patients with PD were classified as without cognitive impairment ( = 32), with mild cognitive impairment ( = 23), and PDD ( = 50), according to their score on clinical dementia rating. Multivariate regression analysis was performed considering age, education, and disease severity as covariates and mild cognitive impairment or dementia as outcome variables. Receiver operating characteristic curve analysis was carried out to derive the optimal cut-off points.
The cut-off point >2.5 (sensitivity = 86.96%, area under curve (AUC) = 0.88) was obtained for discriminating patients with mild cognitive impairment from those without cognitive impairment based on the total score of QDRS. The cut-off point >5 (sensitivity = 84%, AUC = 0.84) was derived for discriminating mild cognitive impairment from dementia based on the total score of QDRS.
The results of this study showed a good discriminative validity of the QDRS for discriminating mild cognitive impairment from no cognitive impairment and dementia in patients with PD.IMPLICATIONS FOR REHABILITATIONThe Quick Dementia Rating System has a good discriminative validity for diagnosing mild cognitive impairment from normal cognitive function in Parkinson's disease.The Quick Dementia Rating System has a good discriminative validity for diagnosing mild cognitive impairment from dementia in Parkinson's disease.The Quick Dementia Rating System could be suggested as a routine rapid cognitive screening tool for patients with Parkinson's disease.
本研究旨在探讨快速痴呆评定量表（QDRS）区分伴有轻度认知障碍、无认知障碍和痴呆的帕金森病（PD）患者的能力。
根据临床痴呆评定量表评分，将 105 例 PD 患者分为无认知障碍（ = 32）、轻度认知障碍（ = 23）和 PD 痴呆（ = 50）。考虑年龄、教育程度和疾病严重程度作为协变量，将轻度认知障碍或痴呆作为因变量进行多元回归分析。进行受试者工作特征曲线分析以获得最佳截断值。
根据 QDRS 总分，区分无认知障碍患者与轻度认知障碍患者的最佳截断值>2.5（敏感性=86.96%，曲线下面积（AUC）=0.88）。根据 QDRS 总分，区分轻度认知障碍与痴呆的最佳截断值>5（敏感性=84%，AUC=0.84）。
本研究结果表明，QDRS 对区分 PD 患者的轻度认知障碍与无认知障碍和痴呆具有良好的判别效度。
快速痴呆评定量表对诊断帕金森病患者的轻度认知障碍与正常认知功能具有良好的判别效度。快速痴呆评定量表对诊断帕金森病患者的轻度认知障碍与痴呆具有良好的判别效度。快速痴呆评定量表可作为帕金森病患者的常规快速认知筛查工具。
