Department of Interventional Radiology, the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13557-13561. doi: 10.1002/anie.202004894. Epub 2020 Jun 3.
The high reactive oxygen species (ROS) generation ability and simple construction of sonosensitizer systems remain challenging in sonodynamic therapy against the hypoxic tumor. In this work, we rationally prepared MOF-derived double-layer hollow manganese silicate nanoparticle (DHMS) with highly effective ROS yield under ultrasound irradiation for multimodal imaging-guided sonodynamic therapy (SDT). The presence of Mn in DHMS increased ROS generation efficiency because it could be oxidized by holes to improve the electron-hole separation. Moreover, DHMS could produce oxygen in the tumor microenvironment, which helps overcome the hypoxia of the solid tumor and thus enhance the treatment efficiency. In vivo experiments demonstrated efficient tumor inhibition in DHMS-mediated SDT guided by ultrasound and magnetic resonance imaging. This work presents a MOF-derived nanoparticle with sonosensitive and oxygen generating ability, which provides a promising strategy for tumor hypoxia in SDT.
声动力学疗法（SDT）针对缺氧肿瘤时，仍面临声敏剂体系产生高活性氧物种（ROS）能力和结构简单这两个挑战。在这项工作中，我们合理制备了具有超声辐照下高效 ROS 生成能力的 MOF 衍生双层空心硅酸锰纳米颗粒（DHMS），用于多模态成像引导的声动力学治疗（SDT）。DHMS 中 Mn 的存在可以通过空穴氧化来提高电子-空穴分离，从而提高 ROS 生成效率。此外，DHMS 可以在肿瘤微环境中产生氧气，有助于克服实体瘤的缺氧，从而提高治疗效率。体内实验证明，超声和磁共振成像引导的 DHMS 介导的 SDT 可有效抑制肿瘤。本工作提出了一种具有声敏性和产氧能力的 MOF 衍生纳米颗粒，为 SDT 中的肿瘤缺氧提供了一种有前途的策略。
