Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA,
Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York, USA.
Cardiorenal Med. 2020;10(4):217-222. doi: 10.1159/000508179. Epub 2020 May 6.
Coronavirus disease 2019 (COVID-19) is a global pandemic affecting more than 200 countries and 180,000 cases in the United States. While the outbreak began in China, the number of cases outside of China exceeded those in China on March 15, 2020 and are currently rising at an exponential rate. The number of fatalities in the United States are expected to exceed more than Italy and China. The disease is characterized predominantly as an acute respiratory illness. However, preliminary data suggests that kidney is a target for the virus and deterioration of renal function was associated with poor outcomes including in-hospital mortality. We pre-sent a report of a patient with COVID-19 who presented with acute onset of symptoms and normal renal function at baseline but rapidly deteriorated resulting in death. The timing of decline in renal function correlated with his worsening clinical status. He was started on continuous veno-venous hemofiltration without signs of clinical benefit. We also present the possible mechanisms for acute kidney injury in these patients. We performed a review of the emerging literature by searching PubMed, Google Scholar, and EMBASE for studies and/or case series published on this topic. Acute kidney injury might help risk stratify critically ill patients on a fatal course of COVID-19.
2019 年冠状病毒病（COVID-19）是一种全球性大流行疾病，影响了 200 多个国家和 18 万美国病例。虽然疫情最初发生在中国，但 2020 年 3 月 15 日，中国以外的病例数超过了中国，并且目前呈指数级增长。美国的死亡人数预计将超过意大利和中国。这种疾病主要表现为急性呼吸道疾病。然而，初步数据表明，肾脏是病毒的靶器官，肾功能恶化与不良结局相关，包括住院死亡率。我们报告了一名 COVID-19 患者的病例，该患者在发病时出现急性症状，基线时肾功能正常，但病情迅速恶化，导致死亡。肾功能下降的时间与他的临床状况恶化相关。他开始接受持续静脉-静脉血液滤过治疗，但没有迹象表明临床获益。我们还提出了这些患者急性肾损伤的可能机制。我们通过搜索 PubMed、Google Scholar 和 EMBASE 上关于这一主题的研究和/或病例系列，对新出现的文献进行了回顾。急性肾损伤可能有助于对 COVID-19 致命病程的危重症患者进行风险分层。
