Ryan Holly, Simmons Chelsey S
J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, PO Box 116250, Gainesville, FL 32611 USA.
Department of Medicine, College of Medicine, University of Florida, Gainesville, USA.
Cell Mol Bioeng. 2020 Aug 31;13(4):305-311. doi: 10.1007/s12195-020-00649-6. eCollection 2020 Aug.
The kidneys are susceptible to adverse effects from many diseases, including several that are not tissue-specific. Acute kidney injury is a common complication of systemic diseases such as diabetes, lupus, and certain infections including the novel coronavirus (SARS-CoV-2). Microfluidic devices are an attractive option for disease modeling, offering the opportunity to utilize human cells, control experimental and environmental conditions, and combine with other on-chip devices. For researchers with expertise in microfluidics, this brief perspective highlights potential applications of such devices to studying SARS-CoV-2-induced kidney injury.
肾脏易受多种疾病的不良影响，包括一些并非组织特异性的疾病。急性肾损伤是糖尿病、狼疮等全身性疾病以及包括新型冠状病毒（SARS-CoV-2）在内的某些感染的常见并发症。微流控设备是疾病建模的一个有吸引力的选择，它提供了利用人类细胞、控制实验和环境条件以及与其他芯片上设备相结合的机会。对于具有微流控专业知识的研究人员来说，这一简短的观点突出了此类设备在研究SARS-CoV-2诱导的肾损伤方面的潜在应用。
