Department of General Surgery, Shiyan Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Department of Urology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China.
Sci Rep. 2021 Apr 13;11(1):8062. doi: 10.1038/s41598-021-87413-6.
The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan-Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.
2019 冠状病毒病（COVID-19）已成为一场前所未有的公共卫生危机。我们回顾性调查了 197 例 COVID-19 患者的临床数据，其中 88 例患者为病情加重病例。与未加重的患者相比，加重患者有更多的合并症，包括高血压（25.9%）和糖尿病（20.8%），并出现呼吸困难（23.4%）、中性粒细胞增多（31.5%）和淋巴细胞减少（46.7%）。这些患者更容易发生肝、肾和心脏等器官损伤（P<0.05）。多变量回归分析显示，高龄、合并症、呼吸困难、淋巴细胞减少以及 Fbg、CTnI、IL-6 和血清铁蛋白水平升高是病情加重的显著预测因素。此外，我们进行了 Kaplan-Meier 分析来评估 COVID-19 患者的预后，结果表明 64.9%的患者没有经历 ICU 转科和从医院存活出院。
