Health and Environmental Sciences Institute, Washington, DC, USA.
Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
EMBO Mol Med. 2020 Jun 8;12(6):e12634. doi: 10.15252/emmm.202012634. Epub 2020 May 27.
Current demand for SARS-CoV-2 testing is straining material resource and labor capacity around the globe. As a result, the public health and clinical community are hindered in their ability to monitor and contain the spread of COVID-19. Despite broad consensus that more testing is needed, pragmatic guidance toward realizing this objective has been limited. This paper addresses this limitation by proposing a novel and geographically agnostic framework (the 4Ps framework) to guide multidisciplinary, scalable, resource-efficient, and achievable efforts toward enhanced testing capacity. The 4Ps (Prioritize, Propagate, Partition, and Provide) are described in terms of specific opportunities to enhance the volume, diversity, characterization, and implementation of SARS-CoV-2 testing to benefit public health. Coordinated deployment of the strategic and tactical recommendations described in this framework has the potential to rapidly expand available testing capacity, improve public health decision-making in response to the COVID-19 pandemic, and/or to be applied in future emergent disease outbreaks.
当前，全球范围内对 SARS-CoV-2 检测的需求给物质资源和劳动力能力带来了压力。因此，公共卫生和临床界在监测和控制 COVID-19 传播方面的能力受到了限制。尽管人们普遍认为需要进行更多的检测，但实现这一目标的实用指导却有限。本文通过提出一个新颖的、与地理位置无关的框架（4Ps 框架）来解决这一限制，该框架旨在指导多学科、可扩展、资源高效和可实现的努力，以增强检测能力。4Ps（优先考虑、传播、划分和提供）是根据具体机会来描述的，这些机会可以提高 SARS-CoV-2 检测的数量、多样性、特征和实施，从而造福公共卫生。协调部署该框架中描述的战略和战术建议，有可能迅速扩大现有检测能力，改善应对 COVID-19 大流行的公共卫生决策，或应用于未来新出现的疾病爆发。
