Mori H, Maeda T, Yamashita H, Makino S, Hayashi Y
Department of Pathology, Osaka Medical College, Japan.
Pathol Res Pract. 1988 Sep;183(5):642-4. doi: 10.1016/S0344-0338(88)80032-3.
More pronounced hyperprolactinemia occurred in the male nude mice bearing a transplantable rat pituitary tumor than in the female nude mice, although the hyperprolactinemia in rats bearing the identical tumors was more prominent in the females than in the males. PRL levels in castrated nude mice of both sexes bearing tumor were almost the same as those in the intact female nude mice. PRL levels in the tumor tissues in each group paralleled relative abundance of PRL-secreting cells in the tumors. Supplement with testosterone or estrogen to the castrated mice recovered the PRL concentrations to the same or higher levels than those in intact male mice. Reproductive organs in the tumor-bearing male nude mice showed no alterations, whereas those in the female nude mice were markedly atrophic. Tumors had receptors for estrogen but not for androgen. Insufficient estrogen secretion due to the ovarian atrophy caused by the PRL from the tumors seemed responsible for the failure in growth of PRL-secreting tumor cells and consequent low PRL production by the tumor.
携带可移植大鼠垂体瘤的雄性裸鼠比雌性裸鼠出现更明显的高催乳素血症，尽管携带相同肿瘤的大鼠中，高催乳素血症在雌性中比在雄性中更突出。两性去势且携带肿瘤的裸鼠的催乳素水平与完整雌性裸鼠的几乎相同。每组肿瘤组织中的催乳素水平与肿瘤中催乳素分泌细胞的相对丰度平行。给去势小鼠补充睾酮或雌激素可使催乳素浓度恢复到与完整雄性小鼠相同或更高的水平。携带肿瘤的雄性裸鼠的生殖器官无变化，而雌性裸鼠的生殖器官明显萎缩。肿瘤有雌激素受体但无雄激素受体。肿瘤分泌的催乳素导致卵巢萎缩，雌激素分泌不足似乎是催乳素分泌肿瘤细胞生长失败及肿瘤催乳素分泌量低的原因。
