Investigation on photo-induced mechanistic activity of GO/TiO hybrid nanocomposite against wound pathogens.

Pathogenic microorganism delays wound-healing process by causing infection. In recent years, researchers have developed various kinds of photo-active nanomaterials with enhanced antibacterial properties. This work focus on the preparation of graphene oxide and TiO nanocomposites (GO/TiO) as a visible light-induced high efficiency antibacterial material. The hydrothermal method was used for the synthesis of GO/TiO nanocomposites at 180 C for 3 h with different loading percentages of GO (10, 20, 30, 40 and 50 wt. %). The systematic characterization tools including X-ray diffraction analysis, FT-IR, UV-vis, Raman and TEM which were used to understand the physicochemical properties of the prepared GO/TiO nanocomposites. Furthermore, GO/TiO nanocomposites were used as photocatalytic active materials against wound infection-causing bacteria in the presence of visible light irradiation. The possible antibacterial mechanism under presence and absence of light were depicted. The antibacterial mechanism of the GO/TiO nanocomposite was investigated on wound infection-causing bacteria such as The high hemocompatibility and the cellular biocompatibility of the nanocomposite aids in using it for wound-healing application. Overall, the results suggest that the GO/TiO nanocomposite could be developed as a photo-active nanomaterial against pathogenic microorganisms that are present in wound.