Prakash Jayabal, Venkataprasanna Kannan Sampath Kumar, Prema Darmalingam, Sahabudeen Sheik Mohideen, Debashree Banita Samal, Venkatasubbu Gopinath Devanand
Department of Nanotechnology, SRM Institute of Science and Technology, Kaatankulathur, Tamil Nadu, India.
Department of Biotechnology, SRM Institute of Science and Technology, Kaatankulathur, Tamil Nadu, India.
Toxicol Mech Methods. 2020 Sep;30(7):508-525. doi: 10.1080/15376516.2020.1765061. Epub 2020 May 23.
Pathogenic microorganism delays wound-healing process by causing infection. In recent years, researchers have developed various kinds of photo-active nanomaterials with enhanced antibacterial properties. This work focus on the preparation of graphene oxide and TiO nanocomposites (GO/TiO) as a visible light-induced high efficiency antibacterial material. The hydrothermal method was used for the synthesis of GO/TiO nanocomposites at 180 C for 3 h with different loading percentages of GO (10, 20, 30, 40 and 50 wt. %). The systematic characterization tools including X-ray diffraction analysis, FT-IR, UV-vis, Raman and TEM which were used to understand the physicochemical properties of the prepared GO/TiO nanocomposites. Furthermore, GO/TiO nanocomposites were used as photocatalytic active materials against wound infection-causing bacteria in the presence of visible light irradiation. The possible antibacterial mechanism under presence and absence of light were depicted. The antibacterial mechanism of the GO/TiO nanocomposite was investigated on wound infection-causing bacteria such as The high hemocompatibility and the cellular biocompatibility of the nanocomposite aids in using it for wound-healing application. Overall, the results suggest that the GO/TiO nanocomposite could be developed as a photo-active nanomaterial against pathogenic microorganisms that are present in wound.
致病微生物通过引起感染来延缓伤口愈合过程。近年来，研究人员开发了各种具有增强抗菌性能的光活性纳米材料。这项工作重点在于制备氧化石墨烯和TiO纳米复合材料（GO/TiO）作为一种可见光诱导的高效抗菌材料。采用水热法在180℃下反应3小时，以不同的GO负载百分比（10、20、30、40和50 wt.%）合成GO/TiO纳米复合材料。使用包括X射线衍射分析、傅里叶变换红外光谱、紫外可见光谱、拉曼光谱和透射电子显微镜在内的系统表征工具来了解所制备的GO/TiO纳米复合材料的物理化学性质。此外，在可见光照射下，GO/TiO纳米复合材料被用作针对引起伤口感染的细菌的光催化活性材料。描绘了在有光和无光情况下可能的抗菌机制。研究了GO/TiO纳米复合材料对引起伤口感染的细菌（如……）的抗菌机制。该纳米复合材料的高血液相容性和细胞生物相容性有助于将其用于伤口愈合应用。总体而言，结果表明GO/TiO纳米复合材料可被开发成为一种针对伤口中存在的致病微生物的光活性纳米材料。
