Winnicka M M, Boguszewicz J, Braszko J
Department of Pharmacology, Medical Academy, Bialystok, Poland.
Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):129-34.
Our earlier experiments have shown that facilitating action of angiotensin II (AII) on recall of passive avoidance is mediated by dopaminergic systems. In an attempt to evaluate the possible site of action of AII on memory processes, bilateral lesions of the structures belonging to the limbic system, receiving efferentation from A 10 dopaminergic neurons were made before behavioral testing of the influence of intracerebroventricular (icv) AII injection on recall in a passive avoidance situation. Bilateral lesions of the nucleus centralis corporis amygdaloidei totally abolished the facilitating effect of AII on recall, while the lesions of the nucleus septi lateralis were ineffective. These results may suggest that improvement of recall in passive avoidance situation after icv injection of AII is mediated by A 10 dopaminergic neurons projecting to the central amygdala.
我们早期的实验表明，血管紧张素II（AII）对被动回避记忆的促进作用是由多巴胺能系统介导的。为了评估AII对记忆过程可能的作用位点，在行为测试脑室内（icv）注射AII对被动回避情境下记忆的影响之前，对属于边缘系统且接受A10多巴胺能神经元传出纤维的结构进行双侧损伤。杏仁核中央核的双侧损伤完全消除了AII对记忆的促进作用，而外侧隔核的损伤则无效。这些结果可能表明，icv注射AII后被动回避情境下记忆的改善是由投射到中央杏仁核的A10多巴胺能神经元介导的。
