Winnicka M M, Braszko J, Boguszewicz J, Wiśniewski K
Pol J Pharmacol Pharm. 1985 Nov-Dec;37(6):897-901.
The experiments performed earlier in this Department indicated that facilitatory effect of angiotensin II (AII) on recall is connected with its influence on dopaminergic systems. In an attempt to evaluate the possible site of action of AII on the memory processes, bilateral lesion of the nucleus accumbens septi (NAS, a limbic structure which receives projection from A 10 dopaminergic neurons) was made before behavioral testing of the influence of icv injection of AII on recall in passive avoidance situation. Unexpectedly, bilateral lesion of the NAS improved the recall itself. In such a situation any facilitatory action of AII on recall in this test could not be shown.
本部门早期进行的实验表明，血管紧张素II（AII）对记忆再现的促进作用与其对多巴胺能系统的影响有关。为了评估AII在记忆过程中可能的作用位点，在通过脑室内注射AII对被动回避情境下的记忆再现影响进行行为测试之前，对伏隔核（NAS，一个接受A10多巴胺能神经元投射的边缘结构）进行了双侧损伤。出乎意料的是，NAS的双侧损伤改善了记忆再现本身。在这种情况下，无法显示AII在该测试中对记忆再现的任何促进作用。
