呋喃并[3,4-d]嘧啶衍生物的合成及其抗肿瘤作用
Synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives.
作者信息
Machoń Z, Cieplik J
机构信息
Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
出版信息
Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):201-8.
PMID:3237569
Abstract
Furo[3,4-d]pyrimidine was obtained in the reaction of 2-phenyl-4-phenylamino-6-methyl-5-pyrimidinecarboxylic acid with SOCl2. This compound, heated with aliphatic amines, yielded mono- and diamino-derivatives. Some of the obtained compounds exhibited a potent antineoplastic activity.
摘要
2-苯基-4-苯基氨基-6-甲基-5-嘧啶羧酸与亚硫酰氯反应制得呋[3,4-d]嘧啶。该化合物与脂肪胺加热反应，生成单氨基和二氨基衍生物。所得到的一些化合物表现出强效抗肿瘤活性。
Zotero 插件