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呋喃并[3,4-d]嘧啶衍生物的合成及其抗肿瘤作用

Synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives.

作者信息

Machoń Z, Cieplik J

机构信息

Department of Organic Chemistry, Medical Academy, Wrocław, Poland.

出版信息

Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):201-8.

PMID:3237569
Abstract

Furo[3,4-d]pyrimidine was obtained in the reaction of 2-phenyl-4-phenylamino-6-methyl-5-pyrimidinecarboxylic acid with SOCl2. This compound, heated with aliphatic amines, yielded mono- and diamino-derivatives. Some of the obtained compounds exhibited a potent antineoplastic activity.

摘要

2-苯基-4-苯基氨基-6-甲基-5-嘧啶羧酸与亚硫酰氯反应制得呋[3,4-d]嘧啶。该化合物与脂肪胺加热反应，生成单氨基和二氨基衍生物。所得到的一些化合物表现出强效抗肿瘤活性。

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Synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives.呋喃并[3,4-d]嘧啶衍生物的合成及其抗肿瘤作用
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Efficient synthesis and biological evaluation of some 2,4-diamino-furo[2,3-d]pyrimidine derivatives.一些 2,4-二氨基呋喃并[2,3-d]嘧啶衍生物的高效合成及生物评价。
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Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.新型C-5取代嘧啶和呋喃并[2,3-d]嘧啶4',5'-二脱氢-L-抗坏血酸衍生物的合成、抗病毒及细胞生长抑制活性评价
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