Gomez S, Vicente V, Ochotorena M M, Hernandez-Gil A
Department of Pathology, Faculty of Medicine, University of Murcia, Spain.
Pigment Cell Res. 1988;1(6):390-6. doi: 10.1111/j.1600-0749.1988.tb00141.x.
We describe an experimental model for the induction of cutaneous melanomas in albino guinea pigs by means of repeated topical application of 7,12-dimethyl-benzanthracene over 13 consecutive months. At the end of the experiment 87.5% of the animals presented multiple lesions of a melanocytic nature. The most frequent and the earliest detected was melanocytic hyperplasia, followed by dysplasia. These lesions occurred in 75% of animals and were observed from the 4th month onward. Nevus-type lesions appeared from the 12th month and affected 70% of animals, whilst melanomas occurred in 65%. Metastases were observed in 45% of animals, in lungs, lymph nodes, kidney, and adrenal gland.
我们描述了一种通过连续13个月重复局部应用7,12 - 二甲基苯并蒽在白化豚鼠中诱导皮肤黑色素瘤的实验模型。实验结束时，87.5%的动物出现了多种黑素细胞性病变。最常见且最早检测到的是黑素细胞增生，其次是发育异常。这些病变出现在75%的动物中，从第4个月开始观察到。痣样病变从第12个月开始出现，影响了70%的动物，而黑色素瘤出现在65%的动物中。在45%的动物中观察到转移，转移部位包括肺、淋巴结、肾脏和肾上腺。
