Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea.
Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, South Korea; Chonnam National University Medical School, Gwangju, South Korea.
Int J Infect Dis. 2020 Jun;95:441-443. doi: 10.1016/j.ijid.2020.04.083. Epub 2020 May 4.
From a total of 71 laboratory-confirmed cases, three presymptomatic patients and 10 patients with entirely asymptomatic infections were identified. In two of the three incubation period patients, the viral titer in the presymptomatic period was very high (Ct value<20). The median number of days to first negative RT-PCR in the asymptomatic carriers was 4.5 (range 2.5-9), and all asymptomatic carriers reached a first RT-PCR Ct>35 within 14 days after diagnosis. Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases.
在总共 71 例实验室确诊病例中，发现了 3 例潜伏期患者和 10 例完全无症状感染患者。在这 3 例潜伏期患者中，有 2 例患者的病毒载量在潜伏期非常高（Ct 值<20）。无症状感染者首次 RT-PCR 转为阴性的中位数时间为 4.5 天（范围 2.5-9 天），所有无症状感染者在诊断后 14 天内均达到首次 RT-PCR Ct 值>35。有 COVID-19 的患者在出现症状之前可能已经具有传染性，在完全无症状的情况下，诊断后进行 14 天的隔离可能就足够了。
