癌症中的异质核核糖核蛋白（hnRNPL）。

Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer.

机构信息

Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, PR China.

出版信息

Clin Chim Acta. 2020 Aug;507:286-294. doi: 10.1016/j.cca.2020.04.040. Epub 2020 May 4.

DOI:10.1016/j.cca.2020.04.040

Abstract

Heterogeneous nuclear ribonucleoprotein L (hnRNPL) is a type of RNA binding protein that is mainly located in the nucleus. hnRNPL protein, encoded by the gene located at 19q13.2, is an important member of the hnRNP family. In recent years, studies have shown that hnRNPL is highly expressed in a variety of tumors and plays a vital role in tumor progression. hnRNPL promotes various biological processes of tumor cells, including proliferation, migration and invasion. In this review, we discuss the clinical significance of hnRNPL by reviewing the mechanism of hnRNPL in the tumorigenesis of various cancers.

摘要

异质核核糖核蛋白 L (hnRNPL) 是一种主要位于细胞核内的 RNA 结合蛋白。hnRNPL 蛋白由位于 19q13.2 上的基因编码，是 hnRNP 家族的重要成员。近年来的研究表明，hnRNPL 在多种肿瘤中高表达，在肿瘤进展中发挥着重要作用。hnRNPL 促进肿瘤细胞的各种生物学过程，包括增殖、迁移和侵袭。在本文中，我们通过综述 hnRNPL 在各种癌症发生中的作用机制，探讨了 hnRNPL 的临床意义。