Ignat'eva E V, Chesnokova V M, Iunker V M, Ivanova L N, Tepelina O M
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):83-6.
The paper is concerned with the effect of thymosin, a hormone secreted by the thymus (fraction 5), on the development of adrenocortical and sex gland functions in genetically athymic mice (nude mutation). Multiple administration of thymosin to mice in the 1st month of their life (0.1 microgram/mouse twice a week) caused the suppression of corticosterone production by the adrenal glands in adult mice aged 2 mos., a considerable rise of the blood level of testosterone in male mice and the reduction of the specific production of estradiol by the ovaries in females. A thymosin-mediated role in the interaction between the immune and endocrine systems in the period of development of their functions was discussed.
本文关注胸腺素（胸腺分泌的一种激素，即第5组分）对基因缺陷型无胸腺小鼠（裸突变）肾上腺皮质和性腺功能发育的影响。在小鼠出生后的第1个月多次给予胸腺素（0.1微克/只，每周两次），导致2月龄成年小鼠肾上腺皮质酮分泌受到抑制，雄性小鼠血液中睾酮水平显著升高，雌性小鼠卵巢雌二醇的特异性分泌减少。文中讨论了胸腺素在免疫系统和内分泌系统功能发育阶段相互作用中的介导作用。
