Department of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Department of Pathology and Population Medicine, Midwestern University, Glendale, Arizona, USA.
Vet Rec. 2020 Oct 17;187(8):e58. doi: 10.1136/vr.105740. Epub 2020 May 6.
Stress-induced anorexia is common in cats. While medications are available to stimulate appetite, many require oral administration, have delayed onset-of-action or cause adverse side effects. The aim of this study was to determine whether cats diagnosed with stress-induced anorexia given a subhypnotic dose of intravenous propofol would have increased short-term appetite as compared to those given placebo.
Anorexic shelter cats received either 1 mg/kg propofol or 1 mL saline placebo and then presented with various commercial cat foods. Grams of food consumed was measured at 15 and 30 min, and total grams compared between treatment and control groups using the Wilcoxon rank-sum test. 12 cats were enrolled, with six cats randomly assigned to each group.
The median amount consumed by the treatment group was 31 g (range: 0-72), with the median for the four cats (67 per cent) who consumed food being 45 g (range: 26-72), or 49 per cent of their daily maintenance calorie requirement. The median amount consumed by control cats was 0 g (range: 0-5), with one cat consuming food. Total grams consumed was different between treatment and control groups (P=0.05).
A subhypnotic dose of intravenous propofol increased appetite in cats with stress-induced anorexia for a 30 min period.
压力引起的厌食在猫中很常见。虽然有药物可以刺激食欲，但许多药物需要口服，起效时间延迟或引起不良反应。本研究旨在确定诊断为应激性厌食的猫接受亚催眠剂量的静脉注射异丙酚是否会比接受安慰剂的猫短期食欲增加。
厌食的收容所猫接受 1mg/kg 异丙酚或 1ml 生理盐水安慰剂，然后呈现各种商业猫粮。在 15 分钟和 30 分钟时测量消耗的食物克数，并使用 Wilcoxon 秩和检验比较治疗组和对照组之间的总克数。共纳入 12 只猫，每组 6 只猫随机分配。
治疗组的中位数消耗量为 31 克（范围：0-72），其中 4 只猫（67%）的中位数消耗量为 45 克（范围：26-72），即 49%的每日维持热量需求。对照组猫的中位数消耗量为 0 克（范围：0-5），其中 1 只猫进食。治疗组和对照组之间消耗的总克数不同（P=0.05）。
亚催眠剂量的静脉注射异丙酚可在应激性厌食猫中增加食欲，持续 30 分钟。
