Miron I, Dumitrascu D L
"Iuliu Hatieganu" University of Medicine and Pharmacy, 3 Medical Clinic, Cluj-Napoca, Romania.
"Iuliu Hatieganu" Dept of Internal Medicine, Cluj-Napoca, Romania.
Acta Endocrinol (Buchar). 2019 Oct-Dec;15(4):497-504. doi: 10.4183/aeb.2019.497.
The gastrointestinal (GI) motility, which is important for the digestion and absorption, may be altered in obesity. The aim of this review is to present the GI motility changes occurring in obesity, as well as their underlying mechanisms. We have conducted a systematic review of the published literature concerning GI motility and obesity and have described recent published data on the changes throughout the entire GI tract. Most recent discoveries include evidence supporting the increase of gastroesophageal reflux disease in obesity and inhibition of gastric motility. Intestinal transit of the distal small bowel generally slows down, ensuring enough time for digestion and absorption. Constipation is more frequent in obese patients than in those with a normal weight. The gut-brain axis plays an important role in the pathophysiology of GI motility disorders in obesity. This bidirectional communication is achieved by way of neurons, hormones, metabolites derived from intestinal microbiota and cytokines. The molecular mechanisms of GI motility changes in obesity are complex. Current data offer a starting point for further research needed to clarify the association of obesity with GI motility disorders.
对消化和吸收至关重要的胃肠动力在肥胖症中可能会发生改变。本综述的目的是阐述肥胖症中出现的胃肠动力变化及其潜在机制。我们对已发表的有关胃肠动力和肥胖症的文献进行了系统综述，并描述了近期发表的关于整个胃肠道变化的数据。最新发现包括支持肥胖症中胃食管反流病增加和胃动力受抑制的证据。远端小肠的肠道转运通常会减慢，以确保有足够的时间进行消化和吸收。肥胖患者比体重正常者更常出现便秘。肠-脑轴在肥胖症胃肠动力障碍的病理生理学中起重要作用。这种双向交流是通过神经元、激素、肠道微生物群衍生的代谢产物和细胞因子实现的。肥胖症中胃肠动力变化的分子机制很复杂。目前的数据为进一步研究肥胖症与胃肠动力障碍之间的关联提供了一个起点。
