胃饥饿素——生理功能与调节
Ghrelin - Physiological Functions and Regulation.
作者信息
Ibrahim Abdalla Mona Mohamed
机构信息
Senior Lecturer, Physiology Department, Faculty of Medicine, MAHSA University, Malaysia.
出版信息
Eur Endocrinol. 2015 Aug;11(2):90-95. doi: 10.17925/EE.2015.11.02.90. Epub 2015 Aug 19.
Abstract
Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates appetite and growth hormone (GH) release. Studies have provided evidence that ghrelin exercises a wide range of functions, including regulation of food intake and energy metabolism, modulation of cardiovascular function, stimulation of osteoblast proliferation and bone formation and stimulation of neurogenesis and myogenesis. In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility and pancreatic protein output. Most of these functions have been attributed to the actions of acylated ghrelin. The balance among its secretion rate, degradation rate and clearance rate determines the circulating level of ghrelin. This review explains what ghrelin is, its physiological functions and the factors that influence its level.
摘要
胃饥饿素是一种主要由胃分泌的促食欲肽，可刺激食欲和生长激素（GH）释放。研究已提供证据表明，胃饥饿素具有广泛的功能，包括调节食物摄入和能量代谢、调节心血管功能、刺激成骨细胞增殖和骨形成以及刺激神经发生和肌发生。在胃肠系统中，胃饥饿素影响多种功能，包括胃酸分泌、胃动力和胰腺蛋白质分泌。这些功能大多归因于酰化胃饥饿素的作用。其分泌速率、降解速率和清除速率之间的平衡决定了胃饥饿素的循环水平。本综述解释了胃饥饿素是什么、其生理功能以及影响其水平的因素。
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