Département de Neurosciences, Groupe de recherche sur le système nerveux central (GRSNC), Université de Montréal, Pavillon Paul-G. Desmarais, C.P. 6128, Succursale Centre-ville, Montréal, Québec, H3C 3J7, Canada.
Cereb Cortex. 2020 Jul 30;30(9):5121-5146. doi: 10.1093/cercor/bhaa106.
We tested the hypothesis that the entopeduncular (EP) nucleus (feline equivalent of the primate GPi) and the globus pallidus (GPe) contribute to both the planning and execution of locomotion and voluntary gait modifications in the cat. We recorded from 414 cells distributed throughout these two nuclei (referred to together as the pallidum) while cats walked on a treadmill and stepped over an obstacle that advanced towards them. Neuronal activity in many cells in both structures was modulated on a step-by-step basis during unobstructed locomotion and was modified in the step over the obstacle. On a population basis, the most frequently observed change, in both the EP and the GPe, was an increase in activity prior to and/or during the swing phase of the step over the obstacle by the contralateral forelimb, when it was the first limb to pass over the obstacle. Our results support a contribution of the pallidum, in concert with cortical structures, to the control of both the planning and the execution of the gait modifications. We discuss the results in the context of current models of pallidal action on thalamic activity, including the possibility that cells in the EP with increased activity may sculpt thalamo-cortical activity.
我们检验了这样一个假设，即被盖（EP）核（灵长类动物 GPi 的对应物）和苍白球（GPe）既有助于规划和执行猫的运动，也有助于自愿改变步态。我们在猫在跑步机上行走并越过向它们前进的障碍物时，记录了分布在这两个核（统称为苍白球）中的 414 个细胞的活动。在无障碍行走过程中，许多细胞在这两个结构中的活动都按部就班地进行了调节，并且在越过障碍物时进行了修改。在群体基础上，在 EP 和 GPe 中观察到的最常见的变化是，当对侧前肢首先越过障碍物时，在越过障碍物的步幅的摆动阶段之前和/或期间，活动增加。我们的结果支持了苍白球与皮质结构共同参与对步态改变的规划和执行的控制。我们在当前关于苍白球对丘脑活动的作用的模型背景下讨论了这些结果，包括活动增加的 EP 中的细胞可能塑造丘脑-皮质活动的可能性。
