Pogledic Ivana, Schwartz Ernst, Mitter Christian, Baltzer Pascal, Milos Ruxandra-Iulia, Gruber Gerlinde Maria, Brugger Peter C, Hainfellner Johannes, Bettelheim Dieter, Langs Georg, Kasprian Gregor, Prayer Daniela
Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Computational Imaging Research Lab, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Cereb Cortex. 2020 Jul 30;30(9):5038-5048. doi: 10.1093/cercor/bhaa099.
The subplate (SP) is a transient structure of the human fetal brain that becomes the most prominent layer of the developing pallium during the late second trimester. It is important in the formation of thalamocortical and cortico-cortical connections. The SP is vulnerable in perinatal brain injury and may play a role in complex neurodevelopmental disorders, such as schizophrenia and autism. Nine postmortem fetal human brains (19-24 GW) were imaged on a 3 Tesla MR scanner and the T2-w images in the frontal and temporal lobes were compared, in each case, with the histological slices of the same brain. The brains were confirmed to be without any brain pathology. The purpose of this study was to demonstrate that the superficial SP (sSP) and deep SP (dSP) can be discriminated on postmortem MR images. More specifically, we aimed to clarify that the observable, thin, hyperintense layer below the cortical plate in the upper SP portion on T2-weighted MR images has an anatomical correspondence to the histologically established sSP. Therefore, the distinction between the sSP and dSP layers, using clinically available MR imaging methodology, is possible in postmortem MRI and can help in the imaging interpretation of the fetal cerebral layers.
板下层（SP）是人类胎儿大脑中的一个短暂结构，在妊娠中期晚期成为发育中的大脑皮层最显著的一层。它在丘脑皮质和皮质皮质连接的形成中起重要作用。板下层在围产期脑损伤中易受影响，可能在复杂的神经发育障碍如精神分裂症和自闭症中起作用。对9个死后胎儿人脑（19 - 24孕周）在3特斯拉磁共振成像扫描仪上进行成像，并将额叶和颞叶的T2加权图像分别与同一大脑的组织学切片进行比较。这些大脑经证实无任何脑部病变。本研究的目的是证明在死后磁共振图像上可以区分浅层板下层（sSP）和深层板下层（dSP）。更具体地说，我们旨在阐明在T2加权磁共振图像上，上板下层部分皮质板下方可观察到的薄的高信号层在解剖学上与组织学确定的sSP相对应。因此，使用临床可用的磁共振成像方法区分sSP和dSP层在死后磁共振成像中是可行的，并且有助于胎儿脑层的成像解读。
