Delpy D T, Cope M, van der Zee P, Arridge S, Wray S, Wyatt J
Department of Medical Physics, University College London, UK.
Phys Med Biol. 1988 Dec;33(12):1433-42. doi: 10.1088/0031-9155/33/12/008.
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations. This result has been verified in a phantom material. Time of flight measurements of pathlength across the rat head give a pathlength of 5.3 +/- 0.3 times the head diameter.
在诸如组织这样的散射介质中对近红外光谱数据进行定量分析需要了解介质中的光程长度。现在可以直接根据皮秒级光脉冲的飞行时间来估计光程长度。对组织中光脉冲的蒙特卡罗模拟表明，时间分散光脉冲的平均值与定量光谱计算中使用的光程长度相关。这一结果已在模拟材料中得到验证。对大鼠头部光程长度的飞行时间测量得出光程长度为头部直径的5.3±0.3倍。
