具有羟基依赖性的水溶性富勒醇用于传染性微生物的高效双光子激发光动力灭活

Kuo Wen-Shuo, Wang Jiu-Yao, Chang Chia-Yuan, Liu Jui-Chang, Shao Yu-Ting, Lin Yen-Sung, So Edmund Cheung, Wu Ping-Ching

School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044, Jiangsu, China.

Allergy & Clinical Immunology Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.

Nanoscale Res Lett. 2020 May 6;15(1):99. doi: 10.1186/s11671-020-03329-6.

We successfully prepared water-soluble fullerenol [C(OH)] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C(OH) with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C(OH) had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C(OH) had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel with 800 scans and a photoexcited wavelength of 760 nm.

我们成功制备了具有高单线态氧量子产率且能有效产生活性氧物种的水溶性富勒醇[C(OH)]。此外，与暴露羟基组成较低的水溶性C(OH)相比，具有较高暴露羟基组成的水溶性C(OH)具有更优异的双光子稳定性和特性。因此，所制备的富勒醇可以成为一种有效的双光子光敏剂。水溶性C(OH)具有良好的双光子性质。在双光子光动力疗法中，水溶性C(OH)在211.2 nJ·像素的超低能量水平、800次扫描以及760 nm的光激发波长下，对大肠杆菌具有显著的抗菌活性。