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Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan.通过液质联用技术和单细胞 RNA 测序进行深度表型分析揭示了 LYN 调控的信号谱，其为单核细胞亚群异质性和寿命的基础。
Circ Res. 2020 May 8;126(10):e61-e79. doi: 10.1161/CIRCRESAHA.119.315708. Epub 2020 Mar 10.
2
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis.平滑肌细胞表型调节的抗动脉粥样硬化作用及单细胞分析揭示的 TCF21 疾病基因。
Nat Med. 2019 Aug;25(8):1280-1289. doi: 10.1038/s41591-019-0512-5. Epub 2019 Jul 29.
3
Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations.单细胞分析正常小鼠主动脉揭示了功能不同的内皮细胞群体。
Circulation. 2019 Jul 9;140(2):147-163. doi: 10.1161/CIRCULATIONAHA.118.038362. Epub 2019 May 31.
4
Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression.单细胞分析命运映射的巨噬细胞揭示了异质性，包括在动脉粥样硬化进展和消退过程中的干性特征。
JCI Insight. 2019 Feb 21;4(4). doi: 10.1172/jci.insight.124574.
5
Circulating CD14CD16 classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients.循环 CD14+CD16+经典单核细胞与易损斑块表型无关，也不能预测严重动脉粥样硬化患者的二级事件。
J Mol Cell Cardiol. 2019 Feb;127:260-269. doi: 10.1016/j.yjmcc.2019.01.002. Epub 2019 Jan 7.
6
Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry.高维质谱细胞术揭示的人单核细胞异质性。
Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):25-36. doi: 10.1161/ATVBAHA.118.311022.
7
The Human Cell Atlas.人类细胞图谱
Elife. 2017 Dec 5;6:e27041. doi: 10.7554/eLife.27041.
8
Monocyte-Macrophages and T Cells in Atherosclerosis.动脉粥样硬化中的单核细胞-巨噬细胞与T细胞
Immunity. 2017 Oct 17;47(4):621-634. doi: 10.1016/j.immuni.2017.09.008.
9
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.克隆性造血与动脉粥样硬化性心血管疾病风险
N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21.
10
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C Cells.鼠源单核细胞的基因组特征揭示了 C/EBPβ 转录因子对 Ly6C 细胞的依赖性。
Immunity. 2017 May 16;46(5):849-862.e7. doi: 10.1016/j.immuni.2017.04.018.

The March of Monocytes in Atherosclerosis: One Cell at a Time.

作者信息

Gupta Rajat M, Lee-Kim Vivian S, Libby Peter

机构信息

From the Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

出版信息

Circ Res. 2020 May 8;126(10):1324-1326. doi: 10.1161/CIRCRESAHA.120.316981. Epub 2020 May 7.

DOI:10.1161/CIRCRESAHA.120.316981
PMID:32379573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7236482/
Abstract
摘要