Tang Rong, Long Tianxin, Lui Kathy O, Chen Yili, Huang Zhan-Peng
Department of Cardiology, Center for Translational Medicine, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, China.
Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China.
Mol Ther Nucleic Acids. 2020 Jun 5;20:673-686. doi: 10.1016/j.omtn.2020.04.007. Epub 2020 Apr 25.
With the continuous development of RNA biology and massive genome-wide transcriptome analysis, more and more RNA molecules and their functions have been explored in the last decade. Increasing evidence has demonstrated that RNA-related regulatory networks play an important role in a variety of human diseases, including cardiovascular diseases. In this review, we focus on RNA regulatory networks in heart disease, most of which are devastating conditions with no known cure. We systemically summarize recent discoveries of important new components of RNA regulatory networks, including microRNAs, long non-coding RNAs, and circular RNAs, as well as multiple regulators that affect the activity of these networks in cardiac physiology and pathology. In addition, this review covers emerging micropeptides, which represent short open reading frames (sORFs) in long non-coding RNA transcripts that may modulate cardiac physiology. Based on the current knowledge of RNA regulatory networks, we think that ongoing discoveries will not only provide us a better understanding of the molecular mechanisms that underlie heart disease, but will also identify novel biomarkers and therapeutic targets for the diagnosis and treatment of cardiac disease.
随着RNA生物学的不断发展以及大规模全基因组转录组分析的开展，在过去十年中，越来越多的RNA分子及其功能被探索。越来越多的证据表明，RNA相关调控网络在包括心血管疾病在内的多种人类疾病中发挥着重要作用。在本综述中，我们聚焦于心脏病中的RNA调控网络，其中大多数是目前尚无已知治愈方法的严重疾病。我们系统地总结了RNA调控网络重要新组成部分的近期发现，包括微小RNA、长链非编码RNA和环状RNA，以及在心脏生理和病理过程中影响这些网络活性的多种调节因子。此外，本综述涵盖了新兴的微肽，它们是长链非编码RNA转录本中的短开放阅读框（sORF），可能调节心脏生理功能。基于目前对RNA调控网络的认识，我们认为不断的发现不仅将使我们更好地理解心脏病的分子机制，还将为心脏病的诊断和治疗识别新的生物标志物和治疗靶点。
