Lanjekar Ashish B, Bhowate Rahul R, Bakhle Suparna, Narayane Abhay, Pawar Vipul, Gandagule Ranjeet
Department of Oral Medicine and Radiology, Swargiya Dadasaheb Kalmegh Smruti Dental College, Nagpur, Maharashtra, India, Phone: +91 9595052481, e-mail:
Department of Oral Medicine and Radiology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
J Contemp Dent Pract. 2020 Jan 1;21(1):83-90.
To study the efficacy of topical curcumin mucoadhesive semisolid gel, triamcinolone acetonide/hyaluronidase mucoadhesive semisolid gel, and a combination of both in the treatment of oral submucous fibrosis (OSMF).
One hundred and twenty patients diagnosed with OSMF were randomly divided into groups I, II, and III. Each patients in groups I, II, and III was given professionally prepared mucoadhesive semisolid gel of curcumin, a combination of triamcinolone acetonide and hyaluronidase mucoadhesive semisolid gel, and a combination of all three, respectively. Patients were instructed to apply the gel thrice daily for 6 weeks on buccal mucosa bilaterally using the tip of index finger. Three parameters were evaluated at the end of each week, namely, mouth opening, burning on visual analog scale (VAS), and the color of oral mucosa on the binary scale. The results were subjected to statistical analysis.
It was observed that the group administered the three drug combinations achieved the greatest mouth opening (mean increase 4.05 mm) as compared to the other two groups. It was observed that triamcinolone and hyaluronidase group reported reduction in burning sensation on VAS (mean difference 6) as compared to the other two groups. It was observed that group III (1% curcumin, 1% hyaluronidase and 0.1% triamcinolone acetonide combined) drug therapy showed better change in mucosa color as compared to groups I (1% curcumin) and II.
Thus, we can conclude that curcumin has a therapeutic effect on patients diagnosed with OSMF. Maximum utilization and enhanced drug delivery were achieved with the help of a combination other two active drugs, namely, triamcinolone and hyaluronidase.
Curcumin role in the treatment of oral cancers and the precancer lesion is very promising.
研究局部应用姜黄素黏膜黏附半固体凝胶、曲安奈德/透明质酸酶黏膜黏附半固体凝胶以及两者联合应用治疗口腔黏膜下纤维化（OSMF）的疗效。
120例诊断为OSMF的患者被随机分为I组、II组和III组。I组、II组和III组的每位患者分别给予专业制备的姜黄素黏膜黏附半固体凝胶、曲安奈德和透明质酸酶黏膜黏附半固体凝胶组合以及三者的联合制剂。指导患者用食指尖每天在双侧颊黏膜上涂抹凝胶3次，持续6周。在每周结束时评估三个参数，即开口度、视觉模拟量表（VAS）上的烧灼感以及二元量表上的口腔黏膜颜色。对结果进行统计分析。
观察到，与其他两组相比，给予三种药物联合制剂的组开口度增加最大（平均增加4.05毫米）。观察到，与其他两组相比，曲安奈德和透明质酸酶组在VAS上的烧灼感有所减轻（平均差异为6）。观察到，与I组（1%姜黄素）和II组相比，III组（1%姜黄素、1%透明质酸酶和0.1%曲安奈德联合）药物治疗在黏膜颜色方面显示出更好的变化。
因此，我们可以得出结论，姜黄素对诊断为OSMF的患者具有治疗作用。借助曲安奈德和透明质酸酶这两种其他活性药物的联合应用，实现了最大程度的利用和增强的药物递送。
姜黄素在口腔癌和癌前病变治疗中的作用非常有前景。
