Department of Oral Medicine and Radiology, Rama Dental College, Hospital and Research Centre, Kanpur, Uttar Pradesh, India.
Department of Oral and Maxillofacial Surgery, Rama Dental College, Hospital and Research Centre, Kanpur, Uttar Pradesh, India.
J Contemp Dent Pract. 2021 Jul 1;22(7):751-755.
This study aims to compare the efficacy of TurmNova lozenges and its active ingredient "curcumin" as a low-cost, safe, and noninvasive chemopreventive agent with intralesional corticosteroids (with hyaluronidase) in the management of oral submucous fibrosis (OSMF).
A total of 80 patients with group III OSMF (Khanna JN and Andrade NN classification) visiting the dental outpatient clinic of the Department of Oral Medicine and Radiology Rama Dental College Hospital and Research Center, Kanpur, were selected for the study. A total of 80 patients were randomly divided into two groups (40 participants each): group A to whom TurmNova® lozenges containing turmeric extract 100 mg along with clove oil 10 mg three times daily for 3 months were given and group B to whom intralesional infiltration of 2 mL dexamethasone (4 mg/mL) + hyaluronidase 1500 IU dissolved in 0.5 mL of 2% lignocaine twice a week for 3 months was given. Data were analyzed using the IBM SPSS Statistics, version 21 (IBM Corp. Released 2012. IBM SPSS Statistics for Windows, version 21.0. Armonk, New York: IBM Corp.) Results: Statistical analysis revealed that there was significant clinical improvement in mouth opening and subjective symptoms, like burning sensation/pain associated with the lesion and tongue protrusion in the group A as compared to group B.
Curcumin (100 mg) in an innovative delivery system of lozenge results in a higher level of plasma curcumin level. The aforementioned dosages prevent its biotransformation and inactivation by the liver enzymes. Because of these properties, curcumin lozenges are safer, low-cost, and effective alternative treatment in contrast to the present traditional treatment. Further long-term, prospective, large-scale studies need to be done.
Curcumin has a role in the treatment of oral premalignant conditions and acts as a very effective chemopreventive agent in the prevention of cancer.
本研究旨在比较 TurmNova 锭剂及其活性成分“姜黄素”作为一种低成本、安全、非侵入性的化学预防剂与局部皮质类固醇（含透明质酸酶）在治疗口腔黏膜下纤维性变（OSMF）中的疗效。
共有 80 名 Khanna JN 和 Andrade NN 分类为 III 级的口腔黏膜下纤维性变患者在 Rama Dental College Hospital and Research Center 的口腔医学和放射学系牙科门诊就诊，被选为研究对象。共有 80 名患者被随机分为两组（每组 40 名）：A 组给予含有 100mg 姜黄提取物和 10mg 丁香油的 TurmNova®锭剂，每日三次，持续 3 个月；B 组给予每周两次局部注射 2ml 地塞米松（4mg/ml）+透明质酸酶 1500IU，溶于 0.5ml 2%利多卡因，持续 3 个月。数据使用 IBM SPSS Statistics，版本 21（IBM Corp. 发布 2012. IBM SPSS Statistics for Windows，版本 21.0. Armonk，纽约州：IBM Corp.）进行分析。结果：统计分析显示，与 B 组相比，A 组患者的张口度和与病变相关的烧灼感/疼痛以及舌伸出等主观症状有显著改善。
创新的锭剂给药系统中的姜黄素（100mg）可使血浆姜黄素水平达到更高水平。上述剂量可防止其被肝脏酶生物转化和失活。由于这些特性，姜黄素锭剂是一种更安全、低成本、有效的替代传统治疗方法。需要进一步进行长期、前瞻性、大规模的研究。
姜黄素在治疗口腔癌前病变方面具有作用，并作为一种非常有效的化学预防剂，可预防癌症。
