腺苷 A2A 受体激动剂通过白细胞介素 6 加速骨愈合并调节 Treg/Th17 细胞平衡。
The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6.
机构信息
Department of SICU, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang District, Beijing, China.
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang District, Beijing, China.
出版信息
Biomed Res Int. 2020 Apr 23;2020:2603873. doi: 10.1155/2020/2603873. eCollection 2020.
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture. We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM 241385/saline locally in rat tibial fracture models, finding that the adenosine A2A receptor agonist could promote fracture healing. At the same time, the adenosine A2A receptor agonist decreased the level of IL-6 in blood and the fracture area, increased Treg cells, and decreased Th17 cells in blood of bone fracture rats. Further, tibial fracture rats implanted with the adenosine A2A receptor agonist gel were injected with IL-6. We found that IL-6 could reverse the effect of adenosine A2A receptor agonists on fracture healing and Treg/Th17 cells in blood. Through the above results, we believe that the adenosine A2A receptor agonist can promote fracture healing and regulate Treg/Th17 cells in blood of rats with fractures. These effects are related to IL-6.
本研究旨在探讨腺苷 A2A 受体激动剂对骨折愈合的影响及其对骨折后免疫系统的调节作用。我们将含有腺苷 A2A 受体激动剂 CGS 21680/抑制剂 ZM 241385/生理盐水的纤维蛋白凝胶局部植入大鼠胫骨骨折模型中，发现腺苷 A2A 受体激动剂可促进骨折愈合。同时，腺苷 A2A 受体激动剂降低了骨折大鼠血液中 IL-6 的水平和骨折面积，增加了血液中的 Treg 细胞，减少了 Th17 细胞。此外，我们在植入腺苷 A2A 受体激动剂凝胶的胫骨骨折大鼠中注射了 IL-6，发现 IL-6 可以逆转腺苷 A2A 受体激动剂对骨折愈合和血液中 Treg/Th17 细胞的影响。通过上述结果，我们认为腺苷 A2A 受体激动剂可以促进骨折愈合，并调节骨折大鼠血液中的 Treg/Th17 细胞。这些作用与 IL-6 有关。
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