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年轻人 1 型糖尿病的种族/民族不平等。

Racial-Ethnic Inequity in Young Adults With Type 1 Diabetes.

机构信息

Fleischer Institute for Diabetes and Metabolism, New York-Regional Center for Diabetes Translational Research, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY.

Jaeb Center for Health Research, Tampa, FL.

出版信息

J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2960-9. doi: 10.1210/clinem/dgaa236.

Abstract

CONTEXT

Minority young adults (YA) currently represent the largest growing population with type 1 diabetes (T1D) and experience very poor outcomes. Modifiable drivers of disparities need to be identified, but are not well-studied.

OBJECTIVE

To describe racial-ethnic disparities among YA with T1D and identify drivers of glycemic disparity other than socioeconomic status (SES).

DESIGN

Cross-sectional multicenter collection of patient and chart-reported variables, including SES, social determinants of health, and diabetes-specific factors, with comparison between non-Hispanic White, non-Hispanic Black, and Hispanic YA and multilevel modeling to identify variables that account for glycemic disparity apart from SES.

SETTING

Six diabetes centers across the United States.

PARTICIPANTS

A total of 300 YA with T1D (18-28 years: 33% non-Hispanic White, 32% non-Hispanic Black, and 34% Hispanic).

MAIN OUTCOME

Racial-ethnic disparity in HbA1c levels.

RESULTS

Non-Hispanic Black and Hispanic YA had lower SES, higher HbA1c levels, and much lower diabetes technology use than non-Hispanic White YA (P < 0.001). Non-Hispanic Black YA differed from Hispanic, reporting higher diabetes distress and lower self-management (P < 0.001). After accounting for SES, differences in HbA1c levels disappeared between non-Hispanic White and Hispanic YA, whereas they remained for non-Hispanic Black YA (+ 2.26% [24 mmol/mol], P < 0.001). Diabetes technology use, diabetes distress, and disease self-management accounted for a significant portion of the remaining non-Hispanic Black-White glycemic disparity.

CONCLUSION

This study demonstrated large racial-ethnic inequity in YA with T1D, especially among non-Hispanic Black participants. Our findings reveal key opportunities for clinicians to potentially mitigate glycemic disparity in minority YA by promoting diabetes technology use, connecting with social programs, and tailoring support for disease self-management and diabetes distress to account for social contextual factors.

摘要

背景

少数民族青年(YA)目前是糖尿病患者中增长最快的群体,他们的治疗效果非常差。需要确定导致这种差异的可改变驱动因素,但目前对此研究还不够充分。

目的

描述青少年 1 型糖尿病(T1D)患者的种族差异,并确定除社会经济地位(SES)以外导致血糖差异的驱动因素。

设计

在美国六个糖尿病中心进行患者和图表报告变量的横断面多中心收集,包括 SES、健康的社会决定因素和糖尿病特定因素,并比较非西班牙裔白种人、非西班牙裔黑人和西班牙裔 YA,以及多层次建模以确定除 SES 以外导致血糖差异的变量。

地点

美国六个糖尿病中心。

参与者

共纳入 300 名青少年 1 型糖尿病患者(18-28 岁:33%非西班牙裔白种人,32%非西班牙裔黑种人,34%西班牙裔)。

主要结局

HbA1c 水平的种族差异。

结果

非西班牙裔黑人和西班牙裔 YA 的 SES 较低,HbA1c 水平较高,糖尿病技术的使用也远低于非西班牙裔白种人(P<0.001)。非西班牙裔黑种人比西班牙裔报告更高的糖尿病困扰和更低的自我管理(P<0.001)。在考虑 SES 后,非西班牙裔白人和西班牙裔 YA 之间的 HbA1c 水平差异消失,而非西班牙裔黑种人之间的差异仍然存在(+2.26%[24mmol/mol],P<0.001)。糖尿病技术的使用、糖尿病困扰和疾病自我管理解释了非西班牙裔黑人和白种人之间剩余血糖差异的很大一部分。

结论

这项研究表明,青少年 1 型糖尿病患者中存在严重的种族差异,尤其是非西班牙裔黑人患者。我们的研究结果揭示了临床医生的重要机会,可以通过促进糖尿病技术的使用、与社会项目联系以及根据社会背景因素调整疾病自我管理和糖尿病困扰的支持,潜在地减轻少数族裔青少年的血糖差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c413/7457963/07f91f40d4ba/dgaa236f0001.jpg

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