University of Geneva, Geneva, Switzerland.
Division of Digestive Surgery, Department of Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland.
Obes Surg. 2020 Aug;30(8):3001-3009. doi: 10.1007/s11695-020-04643-9.
Bariatric surgery is performed mostly on obese women of reproductive age. Many studies have analyzed pregnancy outcomes after bariatric surgery, but only a small number have studied the impact of pregnancy on the postoperative outcomes.
To study the effect of pregnancy on outcomes after bariatric surgery in women of childbearing age.
From January 2010 to October 2017, a retrospective study of a prospectively maintained database was conducted at the University Hospital of Geneva (HUG), where 287 women between the ages of 18 and 45 years had undergone Roux-en-Y gastric bypass (RYGB). A comparison of the results during a 5-year follow-up was performed between women who became pregnant after their bariatric surgery (pregnancy group, n = 40) and postoperative non-pregnant women (non-pregnancy group, n = 247). The two groups were compared for weight loss, complications, and nutritional deficiencies.
The pregnancy group was significantly younger (29.2 ± 5.5 vs. 36.4± 6.3 years, p < 0.001) and heavier (124.0 ± 18.0 kg vs. 114.7 ± 17.1, p < 0.001) compared with the non-pregnancy group at the time of surgery. The percentage of excess BMI loss (%EBMI loss) was similar in both groups during the 5-year follow-up. Complications after RYGB and nutritional deficiencies were nearly identical in the two groups. The interval of time between bariatric surgery and first pregnancy was a median of 20.8 months. Out of 40 first pregnancies, 28 women completed pregnancy successfully with live birth.
Pregnancy after bariatric surgery is safe and does not adversely affect outcomes after RYGB.
减重手术主要针对育龄肥胖女性进行。许多研究分析了减重手术后的妊娠结局，但只有少数研究探讨了妊娠对术后结局的影响。
研究生育年龄女性减重手术后妊娠对结局的影响。
2010 年 1 月至 2017 年 10 月，对日内瓦大学医院（HUG）前瞻性维护数据库进行回顾性研究，对 287 名 18 至 45 岁的女性进行了 Roux-en-Y 胃旁路术（RYGB）。对手术后 5 年随访期间妊娠的女性（妊娠组，n=40）和非妊娠的女性（非妊娠组，n=247）的结果进行比较。比较两组的减重效果、并发症和营养缺乏情况。
妊娠组的年龄显著小于（29.2±5.5 vs. 36.4±6.3 岁，p<0.001），体重显著更重（124.0±18.0 kg vs. 114.7±17.1 kg，p<0.001）。两组在 5 年随访期间的体重指数丢失百分比（%EBMI loss）相似。RYGB 后并发症和营养缺乏在两组几乎相同。减重手术和第一次妊娠之间的时间间隔中位数为 20.8 个月。在 40 例首次妊娠中，28 例女性成功分娩。
减重手术后妊娠是安全的，不会对 RYGB 后的结局产生不利影响。
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