Bjugn R, Flood P R
Institute of Anatomy, University of Bergen, Norway.
Scand J Urol Nephrol. 1988;22(4):313-5. doi: 10.3109/00365598809180806.
Dialyzed and dehydrated human urine and purified Tamm-Horsfall's glycoprotein revealed similar morphology by scanning electron microscopy. Single filaments, with diameters between 15-45 nm, splitting off and merging with thicker fibers at irregular intervals made up a three-dimensional meshwork with submicrometer pores. The resulting "fishing net" is capable of trapping microorganisms and may facilitate their elimination from the urinary tract by micturition. Tamm-Horsfall's glycoprotein may accordingly be a factor protecting against urinary tract infections.
通过扫描电子显微镜观察，透析和脱水后的人类尿液及纯化的Tamm-Horsfall糖蛋白呈现出相似的形态。直径在15至45纳米之间的单丝以不规则间隔从较粗的纤维上分离并与之融合，构成了一个具有亚微米级孔隙的三维网状结构。由此形成的“渔网”能够捕获微生物，并可能通过排尿促进其从尿路中清除。因此，Tamm-Horsfall糖蛋白可能是预防尿路感染的一个因素。
