Meberg A, Haugen H, Akesson I, Sande H
Nephron. 1979;23(1):28-31. doi: 10.1159/000181602.
Uromucoid (Tamm-Horsfall's mucoprotein) was not detected in amniotic fluid from pregnancies with gestational are 12-18 weeks, but was detected in 5 of 9 samples of amniotic fluid from full-term pregnancies, and in urine from all full-term infants investigated 1st day of life. This suggests that uromucoid excretion under normal conditions established near term. Change from intrauterine to extrauterine life may rapidly induce uromucoid excretion, as this protein was found in premature infants (32-34 weeks of gestation) at the 2nd day of life. Healthy newborn infants had a lower uromucoid concentration in urine than children 7--13 years old. In newborns with uncomplicated prematurity, idiopathic respiratory distress syndrome and full-term asphyxiated newborns, the uromucoid concentration in urine during the 1st week of life was not different from healthy newborn infants. Though uromucoid is found to be the major constituent of hyaline casts, the excretion of casts did not correlate to the uromucoid concentration.
在妊娠12 - 18周孕妇的羊水中未检测到尿类黏蛋白（坦 - 霍斯福尔黏蛋白），但在9例足月妊娠孕妇的羊水样本中有5例检测到，并且在所有出生第一天接受调查的足月婴儿的尿液中也检测到。这表明在接近足月时建立了正常情况下尿类黏蛋白的排泄。从宫内生活转变为宫外生活可能会迅速诱导尿类黏蛋白排泄，因为在出生第二天的早产儿（妊娠32 - 34周）中发现了这种蛋白质。健康新生儿尿液中的尿类黏蛋白浓度低于7 - 13岁儿童。在无并发症的早产儿、特发性呼吸窘迫综合征患儿和足月窒息新生儿中，出生后第一周尿液中的尿类黏蛋白浓度与健康新生儿无异。尽管发现尿类黏蛋白是透明管型的主要成分，但管型的排泄与尿类黏蛋白浓度无关。
