红霉素新视角。

A new look at erythromycin.

作者信息

Lacey R W

出版信息

Postgrad Med J. 1977 Apr;53(618):195-200. doi: 10.1136/pgmj.53.618.195.

DOI:10.1136/pgmj.53.618.195

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2496485/

Abstract

This article reviews the current place of erythromycin in antibiotic therapy. Overall, erythromycin is thought to be underused because: (1) the fear of resistance has been exaggerated; (2) significant toxicity has been associated with only one derivative (the estolate); (3) newer antibiotics have very rarely been demonstrated to be superior to erythromycin. Erythromycin has an important place in treating acute upper and lower respiratory tract infections, acute otitis media, sinusitis, skin and soft tissue, osteomyelitis, prostatitis, infections due to Mycoplasma spp. and Chlamydia organisms, and infections due to anaerobes.

摘要

本文综述了红霉素在抗生素治疗中的当前地位。总体而言，红霉素被认为使用不足，原因如下：（1）对耐药性的担忧被夸大；（2）只有一种衍生物（依托红霉素）具有显著毒性；（3）很少有新抗生素被证明优于红霉素。红霉素在治疗急性上、下呼吸道感染、急性中耳炎、鼻窦炎、皮肤及软组织感染、骨髓炎、前列腺炎、支原体属和衣原体属感染以及厌氧菌感染方面具有重要地位。

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