Grammer L C, Shaughnessy M A, Lowenthal M, Yarnold P R
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
J Occup Med. 1994 Jun;36(6):642-6.
Our objective was to identify risk factors for development of immunologically mediated respiratory disease in workers exposed to hexahydrophthalic anhydride. We performed a medical and immunologic survey study of 57 workers in a workplace molding operation utilizing hexahydrophthalic anhydride. The main outcome measurements were the development of a respiratory disease due to specific IgE antibody (asthma and/or rhinitis) or specific IgG antibody (hypersensitivity pneumonitis or hemorrhagic rhinitis). Of the 57 workers, 7 had both IgE- and IgG-mediated disease, whereas 9 had only IgE-mediated disease. Although neither smoking, age, nor race were risk factors for development of immunologically mediated disease, exposure level and specific antibody were. In conclusion, development of immunologically mediated respiratory disease due to hexahydrophthalic anhydride is most closely associated with exposure level and development of specific IgE or IgG antibodies.
我们的目标是确定接触六氢邻苯二甲酸酐的工人发生免疫介导性呼吸道疾病的风险因素。我们对一家使用六氢邻苯二甲酸酐的工厂成型车间的57名工人进行了医学和免疫学调查研究。主要的结局指标是由特异性IgE抗体引起的呼吸道疾病（哮喘和/或鼻炎）或特异性IgG抗体引起的呼吸道疾病（过敏性肺炎或出血性鼻炎）。在这57名工人中，7人患有IgE和IgG介导的疾病，而9人仅患有IgE介导的疾病。虽然吸烟、年龄和种族都不是免疫介导性疾病发生的风险因素，但接触水平和特异性抗体是。总之，六氢邻苯二甲酸酐所致免疫介导性呼吸道疾病的发生与接触水平以及特异性IgE或IgG抗体的产生密切相关。
