Grammer L C, Harris K E, Chandler M J, Flaherty D, Patterson R
Section of Allergy-Immunology, Northwestern University Medical School, Chicago, IL 60611.
J Occup Med. 1987 Oct;29(10):806-11.
Using a questionnaire and serum antibody studies, we evaluated 13 workers exposed to phthalic anhydride (PA) and tetrachlorophthalic anhydride (TCPA). The questionnaire was designed to identify symptoms compatible with anhydride-induced immunologic or irritant syndromes. Specific IgG and IgE for both PA-human serum albumin (PA-HSA) and TCPA-HSA were determined by enzyme-linked immunosorbent assay in two different laboratories. In addition, 11 workers had cutaneous testing with PA-HSA and TCPA-HSA, and nine workers were interviewed. One worker was found to have PA-associated asthma and rhinitis. We conclude that a questionnaire and serologic assays for specific IgG and IgE are helpful to identify workers who have or are at risk for developing occupational immunologic lung disease such as those induced by anhydrides. However, additional evaluation may be necessary in those workers with such diseases as intrinsic asthma that may be difficult to differentiate from occupational immunologic lung disease.
我们使用问卷调查和血清抗体研究，对13名接触邻苯二甲酸酐（PA）和四氯邻苯二甲酸酐（TCPA）的工人进行了评估。该问卷旨在识别与酸酐诱导的免疫或刺激综合征相符的症状。在两个不同实验室通过酶联免疫吸附测定法测定了针对PA - 人血清白蛋白（PA - HSA）和TCPA - HSA的特异性IgG和IgE。此外，11名工人接受了PA - HSA和TCPA - HSA的皮肤试验，9名工人接受了访谈。发现一名工人患有与PA相关的哮喘和鼻炎。我们得出结论，针对特异性IgG和IgE的问卷调查和血清学检测有助于识别患有或有发展为职业性免疫性肺病风险的工人，例如由酸酐诱导的疾病。然而，对于患有诸如特发性哮喘等可能难以与职业性免疫性肺病相区分的疾病的工人，可能需要进行额外评估。
