Emergency Department, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
Department of Surgery, Laishan Branch of Yuhuangding Hospital, Yantai, Shandong, China.
J Fluoresc. 2020 May;30(3):717-723. doi: 10.1007/s10895-020-02547-6. Epub 2020 May 9.
The coordination polymers based on Zn(II) ions and the metal nodes which has chemical formula of {[Zn(L)(tib)(HO)]·(DMF)} (1) was synthesized via using 1,3,5-tris(1-imidazolyl)benzene (tib) and 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid (HL) as ligands under solvothermal conditions. Given its strong luminescent emission at room temperature and the uncoordinated N-donor sites in the framework, the selective detection performance of 1 toward the nitroanalytes was studied, 1's sensitive fluorescence quenching reactions along with selectivity to the electron-deficient TNP over other analytes of nitro within the aqueous phase was studied via the method of fluorescence quenching titration. Furthermore, the treatment effect of the compound on the deep vein thrombosis (DVT) was evaluated. Firstly, the ELISA was carried out to determine IL-17A content. Then, the platelet function was determined via the western blot by measuring expression level of platelet activation signaling pathway protein p-ERK2 and p53.
基于 Zn(II) 离子和金属节点的配位聚合物，其化学式为{[Zn(L)(tib)(HO)]·(DMF)}（1），是通过使用 1,3,5-三(1-咪唑基)苯（tib）和 2,6-二(4-羧基苯基)吡啶-4-羧酸（HL）作为配体，在溶剂热条件下合成的。由于其在室温下具有强发光发射和框架中未配位的 N-供体位点，因此研究了 1 对硝基分析物的选择性检测性能，通过荧光猝灭滴定法研究了 1 与电子缺电子 TNP 之间的灵敏荧光猝灭反应以及对水相中的其他硝基分析物的选择性。此外，还评估了该化合物对深静脉血栓形成（DVT）的治疗效果。首先，通过 ELISA 测定 IL-17A 含量。然后，通过测定血小板激活信号通路蛋白 p-ERK2 和 p53 的表达水平，通过 Western blot 测定血小板功能。
